Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers

Extensive research has been conducted to elucidate and substantiate the crucial role of Renin-Angiotensin System (RAS) in pathogenesis hypertension, cardiovascular disorders, renal diseases. Furthermore, oxidative stress maintaining vascular balance well established. It observed that many cellular effects induced by Angiotensin II (Ang II) are facilitated reactive oxygen species (ROS) produced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this paper, we present a comprehensive overview ROS physiology human blood vessels, specifically focusing on its interaction with RAS. Moreover, delve into mechanisms which clinical interventions targeting RAS influence redox signaling wall.